BBC World News, July 28th, 2010
US researchers have developed a promising new
technique that might one day enable doctors to regrow broken or diseased
joints in patients.
Writing in the The Lancet, US researchers say they have regrown the forelimb thigh joint of rabbits using their own stem cells.
It was the first time an entire joint surface had been regenerated with the return of functions, they said.
The research could benefit patients with damaged hips, shoulders or knees.
The team removed the limbs from 10 rabbits and replaced them with an artificial limb-shaped skeleton.
This was soaked with chemicals which attract bone and cartilage stem cells.
Four weeks later the rabbits had regrown their joints and were able to move normally.
“This is the first time an entire joint surface was
regenerated with return of functions including weight bearing and
locomotion,” said Professor Jeremy Mao of Columbia University Medical
Center, New York.
“Regeneration of cartilage and bone both from the host’s own
stem cells, rather than taking stem cells out of the body, may
ultimately lead to clinical applications. In patients who need the knee,
shoulder, hip or finger joints regenerated, the rabbit model provides a
proof of principle,” he said.

